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Moldovan lab

Contact Information
Nicanor I. Moldovan, PhD
Research Associate Professor
Internal Medicine, Division of Cardiovascular Medicine
Biomedical Research Tower
460 W. 12th Avenue
Room 306
Columbus, Ohio 43210
Phone: 614-247-7801

General Research Interest:

My laboratory focuses on improved definition, detection and bio-medical applications of circulating stem/progenitor cells. The current projects are: 1) Comprehensive detection of endothelial and other progenitor cells in human blood (collectively defined as the 'repairome'), using novel methods inspired from systems biology and cytomics. 2) Identification of biochemical factors, mainly related to redox metabolism, impeding the survival of circulating progenitor cells spontaneously recruited in damaged tissues. 3) Study of the biomechanical factors controlling the traffic of cells in the bloodstream, as limiting the efficiency of cell therapy. In this regard, we defined the cellular resilience to biomechanical stress, based on new computational models that take in consideration the structural role of water. 4) Use of progenitor cells for tissue engineering of peri-implant space. This project proposes a different approach to deal with the ubiquitous 'foreign body' reaction and subsequent fibrous encapsulation affecting implanted biosensors and drug delivery devices: namely, to 'treat' them before impanation with stem/progenitor cells for stimulation of peri-implant neovascularization.

Lab Members

Mirela Anghelina, MD, Senior Research Associate (Lab Manager)
Leni Moldovan, PhD, Research Scientist
Jessica Thomas, BS, Graduate Student (Department of Biomedical Engineering)
Desiree Jones, BS, Research Assistant
Enass Ramadan, BA, Research Assistant
Kristina Blanton, Undergraduate Student

Current Publiations

1. Modeling Stem/Progenitor Cell-Induced Neovascularization and Oxygenation Around Solid Implants. Jain HV, Moldovan NI, Byrne HM. Tissue Eng Part C Methods. 2012 Mar 2. [Epub ahead of print]

2. The stimulation of the cardiac differentiation of mesenchymal stem cells in tissue constructs that mimic myocardium structure and biomechanics. Guan J, Wang F, Li Z, Chen J, Guo X, Liao J, Moldovan NI. Biomaterials. 2011 Aug: 32 (24):5568-80.

3. Dynamics of the cytoskeleton: how much does water matter? Lenormand G, Millet E, Park CY, Hardin CC, Butler JP, Moldovan NI, Fredberg JJ. Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Jun: 83 (6 pt 1): 061918.

4. Regulation of adult hematopoietic stem cells fate for enhanced tissue-specific repair. Sengupta N, Caballero S, Sullivan SM, Chang LJ, Afzal A, Li Calzi S, Kielczewski JL, Prabarakan S, Ellis EA, Moldovan NI, Boulton ME, Grant MB, Scott EW, Harris JR. Mol Ter. 2009 Sep: 17 (9):1594-604.

5. Stimulation of peri-implant vascularization with bone marrow-derived progenitor cells: monitoring by in vivo EPPR oximetry. Butt OI, Carruth R, Kutala VK, Kuppusamy P, Moldovan NI. Tissue Eng. 2007 Aug 13 (8): 2053-61.

6. A subpopulation of peritoneal macrophages from capillary-like lumens and branching patterns in vitro. Anghelina M, Moldovan L, Zabuawala T, Ostrowski MC, Moldovan NI. J Cell Mol Med. 2006 Jul-Sep: 10(3):708-15.


A. Collaborators at Ohio State University:

1. Lowrie Department of Chemical and Biomolecular Engineering: Professors Stuart L. Cooper, Jeff Chalmers, L. James Lee and Michael Paulaitis (Identification of circulating progenitor cells).

2. Department of Materials Science: Professor John Lannutti and Associate Professor Jianjun Guan (Use of electrospun scaffolds for tissue engineering or peri-implant space).

3. Department of Biomedical Engineering: Associate Professors Keith Gooch and Gunjan Agarwal (Optimization of cell seeding for induced neovascularization and other tissue engineering applications).

4. Department of Internal Medicine, Division of Cardiovascular Medicine: Professor Periannan Kuppusamy (Development of the implanted oxygen sensor detectable by EPR oximetry).

5. Department of Computer Sciences: Associate Professor Raghu Machiraju (Multi-parametric image analysis) and Assistant Professor Nicoleta Roman (Cellular automata).

6. Department of Obstetrics and Gynecology: Professor Pravin Kaumaya (Application of peptide ligands to cell capture and targeted inhibition of neovascularization).

7. Department of Endocrinology: Professor William Malarkey (Impact of inflammation on circulating progenitor cells).

8. Mathematical Biosciences Institute: Visiting Scholar Harsh Jain (Modeling oxygen diffusion in peri-implant space and after manipulation by stem cells administration).

B. Collaborators within USA:

1. University of Florida at Gainesville, Professor Maria Grant (Role of circulating cells in retinal damage and repair).

2. Harvard University Medical School, Professor Jeffrey Fredberg (Role of water in cellular biomechanics).

3. Harvard University Medical School, Assistant Professor Daniel Irimia (Microfluidic models of microcirculation).

4. University of Wisconsin at Madison, Professor Amir Assadi (Biostatistics and data mining of gene expression).

C. International Collaborators:

1. Oxford University, UK, Professor Helen Byrne (Mathematical models of neovascularization).

2. University of Rotterdam, Netherlands, Stem Cells Institut, Research Fellow MIchaela Crisan (Progenitor cells for tissue engineering).

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473 W. 12th Ave.
Columbus, OH 43210

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