Marsh Lab Clay Marsh, MD Division of Pulmonary Department of Internal Medicine The Ohio State University 465/455 Davis HLRI 473 West 12th Avenue Columbus, Ohio 43210-1252 Phone: (614) 247-7662 E-mail: marsh-3@medctr.osu.edu Current Research Our laboratory focuses on basic and applied research related to the role of immunoglobulins and macrophage colony-stimulating factor (M-CSF) in and monocyte survival, activation and differentiation. To this end, we are thematically pursuing the mechanisms by which monocytes facilitate and augment inflammation in human diseases and to define biochemical and molecular targets that may be useful to regulate this accumulation. In addition, we are applying these same strategies to understand the biochemical pathways regulating survival in leukemic cells (particularly AML and CML) and in understanding the regulation of atherosclerosis. Moreover, some members of the laboratory focus on the role of monocytes and macrophages in the production and activation of transforming growth factor-b (TGF-b) as it applies to fibrotic diseases. Members of the Group Naeem Ali, Clinical Instructor - House Staff Chris Baran, Graduate Research Associate Nitin Bhatt, Assistant Professor Tim Eubank, Graduate Research Associate Melissa Hunter, PhD, Research Scientist Rosemary Keogh, PhD, Research Scientist Frank Lichtenberger, Medical Student Clay Marsh, MD, Associate Professor Xaiokui (Molly) Mo, Post-Doctoral Researcher Christine Montague, Post-Doctoral Researcher Judy Opalek, Graduate Research Associate Susheela Tridandapani, PhD, Assistant Professor Yijie Wang, Research Associate Mandy Zeigler, Research Associate
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