Marsh Lab

Clay Marsh, MD
Division of Pulmonary
Department of Internal Medicine
The Ohio State University
465/455 Davis HLRI
473 West 12th Avenue
Columbus, Ohio 43210-1252
Phone: (614) 247-7662
E-mail: marsh-3@medctr.osu.edu

Current Research

Our laboratory focuses on basic and applied research related to the role of immunoglobulins and macrophage colony-stimulating factor (M-CSF) in and monocyte survival, activation and differentiation. To this end, we are thematically pursuing the mechanisms by which monocytes facilitate and augment inflammation in human diseases and to define biochemical and molecular targets that may be useful to regulate this accumulation. In addition, we are applying these same strategies to understand the biochemical pathways regulating survival in leukemic cells (particularly AML and CML) and in understanding the regulation of atherosclerosis. Moreover, some members of the laboratory focus on the role of monocytes and macrophages in the production and activation of transforming growth factor-b (TGF-b) as it applies to fibrotic diseases.

Members of the Group

Naeem Ali, Clinical Instructor - House Staff
Chris Baran, Graduate Research Associate
Nitin Bhatt, Assistant Professor
Tim Eubank, Graduate Research Associate
Melissa Hunter, PhD, Research Scientist
Rosemary Keogh, PhD, Research Scientist
Frank Lichtenberger, Medical Student
Clay Marsh, MD, Associate Professor
Xaiokui (Molly) Mo, Post-Doctoral Researcher
Christine Montague, Post-Doctoral Researcher
Judy Opalek, Graduate Research Associate
Susheela Tridandapani, PhD, Assistant Professor
Yijie Wang, Research Associate
Mandy Zeigler, Research Associate

Useful Links

National Institutes of Health
National Library of Medicine
National Center for Biotechnology Information
Predict Protein Server

Online Journals

Journal of Clinical Investigation
Blood
Molecular and Cellular Biology
Cell
Journal of Biological Chemistry
Proceedings of the National Academy of Sciences
Science
Nature
Journal of Immunology