Kuppusamy Lab

Periannan Kuppusamy, PhD
Heart & Lung Research Institute
The Ohio State University
Tzagournis MRF
473 West 12th Avenue
Columbus, Ohio 43210-1252
Phone:
E-mail: kuppusamy-1@medctr.osu.edu

Current Research

Dr. Kuppusamy’s primary interest on the application side of the in vivo EPR technique has been to study myocardial oxygenation, free radical generation and metabolism. Some of the pioneering works that he has performed in this area include (i) imaging of oxygen and free radical metabolism in the intact beating hearts; (ii) gated EPR imaging of free radicals in the beating heart and (iii) in vivo detection and imaging of NO generation following cardio-pulmonary arrest. The high spatial and temporal resolutions in the EPR images enabled to obtain accurate mapping of myocardial oxygenation during cardiac contractile cycle and regional alterations in the NO generation.

A second area of application that Dr. Kuppusamy has initiated in the last few years is to develop and obtain mapping (imaging) of tumor physiology including oxygenation, redox state and heterogeneity, in vivo. As a noninvasive method, the EPR imaging technique has the potential of performing accurate and repeated measurement of oxygen concentration in tumors, which are critical for the treatment of certain tumors using chemo- and radiotherapies. The functional imaging methods enable real-time monitoring of perfusion, oxygenation, and redox state in tumors.

A third area of research program that Dr. Kuppusamy has been currently developing is the efficacy and mechanism of certain novel membrane-permeable, nitroxide-based SOD-mimetic, antiarrhythmic plus antioxidant drugs in protecting against ischemia-reperfusion induced myocardial injury.