Xiaoping Liu

Office Information

601 DHLRI
473 West 12th Ave
Columbus, OH, 43210
Office Phone: (614) 292-1305

Lab Information

635 DHLRI
473 West 12th Ave
Columbus, OH, 43210
Other Phone: (614) 292-4031

Area of Expertise

Mathematical models of diffusion-reaction biotransport problems, analytical and numerical solutions of diffusion-reaction equations, catabolism kinetics of nitric oxide (NO) in the vascular system, and electrochemical techniques and methods for detections of NO, hydrogen peroxide and oxygen in biological systems.

Interest and Subspecialty

Dr. Liu received his Ph.D. in chemistry (1992) from Wuhan University in China. He was a postdoctoral fellow in Shanghai Institute of Physiology from 1992 to 1994 and in Louisiana State University School of Medicine from 1994 to 1998. He joined Johns Hopkins University Medical Institutions in the end of 1998 and was promoted to Instructor of Medicine in January 2001. He came to the Davis Heart and Lung Research Institute at Ohio State in August 2002, where he was appointed as Assistant Professor of Internal Medicine. NO, a potent vasodilator, plays an important role in maintaining vascular tone and regulating blood pressure. Dr. Liu has made unique contributions to studies of NO catabolism kinetics in the vascular system by combining mathematical modeling with newly developed/improved electrochemical detection techniques and methods. He derived closed-form analytical expressions for predicting NO half-life in the solution containing red blood cells (RBCs), for identifying the location of the resistance to NO diffusion into RBCs from experimental data, and for estimating NO concentration in blood at different NO generation rates. Recently, with computer simulations and novel experimental methods, he and his colleagues determined NO diffusion coefficient in the arterial wall. His current interests focus on studying the effect of NO diffusion-reaction related factors to NO bioavailability in hypoxia and in the development of cardiovascular diseases.

Recent Publications

(1) X. Liu, M.J.S. Miller, M.S. Joshi, D.D. Thomas and J.R. Lancaster Jr. Accelerated reaction of nitric oxide with O2 within the hydrophobic interior of biological membranes, Proc. Natl. Acad. Sci. USA, 95: 2175-2179, 1998.

(2) X. Liu, M.J.S. Miller, M.S. Joshi, H. Sadowska-Krowicka, D.A. Clark and J.R. Lancaster Jr. Diffusion-limited reaction of free nitric oxide with erythrocytes. J. Biol. Chem. 273:18709-18713, 1998.

(3) X. Liu, A. Samouilov, J.R. Lancaster Jr., J.L. Zweier. Nitric oxide uptake by erythrocytes is primarily limited by extracellular diffusion Not Membrane Resistance. J. Biol. Chem., 277: 26194-26199, 2002.

(4) X. Liu, Q. Yan, K. L. Baskerville, J. L. Zweier, Estimation of Nitric Oxide Concentration in Blood for Different Rates of Generation: Evidence that intravascular nitric oxide levels are too low to exert physiological effects, J. Biol. Chem. 55(4):329-34, 2007.

(5) X. Liu, P. Srinivasan, E. Collard, P. Grajdeanu, J. L. Zweier and A. Friedman. Nitric oxide diffusion rate is reduced in the aortic wall, Biophysical Journal, 94(5):1880-9, 2008.

Return to full investigator list