Yong Xia

Office Information

605 DHLRI
473 West 12th Ave
Columbus, OH, 43210
Office Phone: (614) 292-5709

Lab Information

626 & 630 DHLRI
473 West 12th Ave
Columbus, OH, 43210
Other Phone: (614) 247-1666 & (614) 247-1667

Area of Expertise

Signal transduction, biochemistry, molecular cardiovascular biology, nitric oxide biology, oxidative stress, free radical biology.

Interest and Subspecialty

The overall research interest of the Xia laboratory is in the molecular mechanisms of cardiovascular regulation and diseases. Specifically, we focus on the function and regulation of nitric oxide synthase (NOS). NO is a fundamental signaling molecule and effector in a variety of biological processes including cardiovascular regulation, neuronal signal transmission, and immune response. In biological system, NO is primarily produced by a family of NOSs. Dr. Xia’s group has pioneered in identifying superoxide generation as a novel function of NOS. This new superoxide generation pathway has now been found to play important roles in cell injury and signal transduction. Current studies in Dr. Xia’s group include signal transduction in cell stresses, molecular mechanism of cell injury, and regulation of NOS by protein-protein interactions, protein phosphorylation, and critical enzyme cofactors. These studies take multi-disciplinary approaches ranging from molecular biology, biochemistry, biophysics to physiology and pharmacology. Other research in the laboratory includes the studies on the mechanism of endothelial dysfunction, a common manifestation of various cardiovascular diseases.

Dr. Xia came from Johns Hopkins University School of Medicine where he first did his postdoctoral fellowship at the Molecular and Cellular Biophysics Laboratories in 1994 and then served as Instructor in Medicine at the Division of Cardiology in 1997. He was promoted to Assistant Professor of Medicine at Johns Hopkins in 1999. In 2003, Dr. Xia joined the Davis Heart & Lung Research Institute of the Ohio State University, where he was appointed as Associate Professor of Medicine. He is also an adjunct Associate Professor in the Department of Molecular and Cellular Biochemistry. The research in Dr. Xia’s laboratory is supported by grants from NIH and American Heart Association (AHA).

Recent Publications

Yoshida, M., and Xia, Y. Heat shock protein 90 as an endogenous protein enhancer of inducible nitric oxide synthase. J. Biol. Chem. 278:36953-36958, 2003.

Wei, Q., and Xia, Y. Roles of 3-phosphoinositide-dependent kinase 1 in the regulation of endothelial nitric oxide synthase phosphorylation and function by heat shock protein 90. J. Biol. Chem. 280:18081-18086, 2005.

Wei, Q., and Xia, Y. Proteasome inhibition down-regulates endothelial nitric oxide synthase phosphorylation and function. J. Biol. Chem. 281:21652-21659, 2006.

Xia, Y. Superoxide generation from nitric oxide synthase. Antioxid. Redox Signal. 9:1771-1778, 2007

Hu, Z., Chen, J., Wei, Q., and Xia, Y. Bidirectional actions of hydrogen peroxide on endothelial nitric oxide synthase phosphorylation and function: co-commitment and interplay of Akt and AMPK. J. Biol. Chem. 2008 Jul. 10. [Epub ahead of print]

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