Dale Vandre

Office Information

304 Hamilton Hall
1645 Neil Ave
Columbus, OH, 43210
Office Phone: (614) 292-4181

Lab Information

012A DHLRI
473 West 12th Ave
Columbus, OH, 43210
Other Phone: (614) 292-7848

Area of Expertise

Interest and Subspecialty

Development of methods for the isolation of highly enriched plasma membrane from human cells and tissues suitable for proteomics analysis using cationic silica based techniques. Using the apical plasma membrane of the placental syncytiotrophoblast as a model system, we are examining the proteome of the microvillus brush border. Further analysis of cultured cell lines that can be induced to differentiate will be used to analyze developmental changes in the proteome of the plasma membrane associated with microvillus and brush border formation. These approaches can be modified for applications designed for the analysis of the plasma membrane of endothelial cells to examine changes in protein profiles associated with perfusion related disorders. We are also examining novel methods for the analysis of low molecular weight serum proteins for disease biomarker analysis using mass spectrometry based technology.

Recent Publications

Marsee, D.K., Venkateswaran, A., Tao, H., Vadysirisack, D., Zhang, Z., Vandre, D.D., and Jhiang, S.M. Inhibition of Heat Shock Protein 90, a Novel RET/PTC1-associated Protein Increases Radioiodide Accumulation in Thyroid Cells. J. Bio. Chem. 279:43990-7, 2004.

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