Hamdy Hassanain

Office Information

316 BRT
460 W12th Ave
Columbus, OH, 43210
Office Phone: (614) 292-1062

Lab Information

340 BRT
460 W12th Ave
Columbus, OH, 43210
Other Phone: (614) 292-1669

Area of Expertise

The function of Rac 1, Profiin 1 and C-Reactive Protein (CRP) in cardiovascular diseases. We study the role of free radical production mediated by Rac gene activation of NADPH oxidase in the development of cardiovascular diseases, such as hypertension, diabetes, ischemia and perfusion injury and heart failure. We also assess the role of profilin mediated actin polymerization in vascular smooth muscle on vascular hypertrophy and role of CRP in developing atherosclerosis.

A series of transgenic animal models have been generated for these studies in my laboratory such as Rac CA, Rac DN, Profilin 1, Corn Rac CA and CRP transgenic mice. For example, the hypertensive mouse model was developed by overexpression of the human Rac CA gene in the blood vessels, while the heart failure model was developed by overexpressing the Zea maize (corn) Rac D gene in the heart of transgenic mice. We are studying the role of Rac 1 and Profilin 1 genes in wound repair using Rac CA, Rac DN and Profilin 1 transgenic animal models.

Interest and Subspecialty

Molecular cardiovascular research, transgenic models for cardiovascular diseases, gene chip analysis to identify putative genes involved in cardiovascular diseases, signal mechanism involved in cardiovascular diseases.

Recent Publications

1. Hassanain, H., Irshaid, F, Krishna, S., Al-kheraije KA, Wisel, S., Sheridan, J., Michler, R.E. and Goldschmidt-Clermont PJ. (2005) Smooth muscle cell expression of a constitutive active form of human Rac 1 accelerates wound repair. Surgery 137(1):92-101.

2. Guzman J, Yu JG, Suntres Z, Bozarov A, Cooke H, Javed N, Auer H, Palatini J, Hassanain HH, Cardounel AJ, Javed A, Grants I, Wunderlich JE, Christofi FL. (2006). ADOA3R as a Therapeutic Target in Experimental Colitis: Proof by Validated High-density Oligonucleotide Microarray Analysis Inflamm Bowel Dis. Aug;12(8):766-789

3. Chen Z, Suntres Z, Palmer J, Guzman J, Javed A, Xue J, Yu JG, Cooke HJ, Awad H, Hassanain HH, Cardounel AJ, FL Christofi. Cyclic AMP Signaling Contributes to Neural Plasticity and Hyperexcitability in AH Sensory Neurons Following Intestinal Trichinella spiralis - induced Inflammation. International Journal of Parasitology 2007 Jun;37(7):743-61. Epub 2007 Jan 14.

4. Hamdy H. Hassanain, David Gregg, Maria Luisa Marcelo, Heraldo P. Souza, Jay L. Zweier, Balakrishnan Selvakumar, Qi Ma, Moustafa B. Moustafa, Phillip F. Binkley, Nicholas A. Flavahan, Mariana Morris, Chunming Dong and Pascal J. Goldschmidt-Clermont (2007). Hypertension Caused by Transgenic Over-expression of Rac1.Antioxidant & Redox Signaling Volume 9 number 1.

5. Moustafa-Bayoumi M, Alhaj MA, El-Sayed O, Wisel S, Chotani MA, Abouelnaga ZA, Hassona MDH, Rigatto K, Morris M, Nuovo G, Zweier JL, Goldschmidt-Clermont P, Hassanain HH. (2007). Vascular Hypertrophy and Hypertension Caused by Transgenic Overexpression of Profilin 1. J. Biol. Chem., Vol. 282, (Issue 52) 37632-37639.

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