Terry Elton

Office Information

515 DHLRI
473 West 12th Ave
Columbus, OH, 43210
Office Phone: (614) 292-1400

Lab Information

524 DHLRI
473 West 12th Ave
Columbus, OH, 43210
Other Phone: (614) 292-9060

Area of Expertise

Angiotensin II Receptor Gene Regulation and Signal Transduction

Interest and Subspecialty

My laboratory investigates the mechanisms by which human angiotensin II type 1 receptor (hAT1R) expression is regulated. A number of studies have demonstrated that hAT1R levels can be regulated by transcriptional and post-transcriptional mechanisms. Additionally, my laboratory has demonstrated that hAT1R expression can be modulated by alternative splicing. We hypothesize that dysregulation of this receptor leads to the overproduction of hAT1Rs which in turn initiates a cascade of pathological events that results in cardiovascular disease. The knowledge gained from our studies may lead to the development of novel therapeutics for the disease states in which aberrant regulation of hAT1R expression occurs.

Recent Publications

Martin, M.M., Buckenberger, J.A., Knoell, D.L., Strauch, A.R. and T.S. Elton. Translational regulation of human AT1 receptor expression by mRNA splice variants harboring exon 2. (Mol Cell Endocrinol, submitted, 2005).

Speth, R.C, Kwan, H.K, Elton, T.S. and S. Simasko. Sarcosine1, Glycine8 angiotensin II is a functional AT1 angiotensin receptor antagonist. Endocrine 26-83-87, 2005.

Duffy, A.A., Martin, M.M. and T.S. Elton. Transcriptional regulation of the AT1 receptor gene in immortalized human trophoblast cells. Biochim Biophys Acta 1680:158-170, 2004.

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