Daniel Birmingham

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Office Information

311 DHLRI
473 West 12th Ave
Columbus, OH, 43210
Office Phone: (614) 688-3842

Lab Information

335 DHLRI
473 West 12th Ave
Columbus, OH, 43210
Other Phone: (614) 688-3844

Area of Expertise

Complement, immune complexes (IC), IC disease, systemic lupus erythematosus (SLE)

Interest and Subspecialty

Our research interests are on the genetics and biology of the complement system, and on the processing and clearance of immune complexes (IC). Current efforts are focused on two areas. First, we are studying the roles that IC clearance proteins (eg. CR1, FcR) and other modulators of IC inflammation play in the pathogenesis of human IC disease, such as systemic lupus erythematosus and IC nephritis. Second, we are characterizing new members of a family of complement proteins known as the regulators of complement activation. This includes proteins that may protect against IC-mediated inflammation and against the development of autoimmunity.

Recent Publications

Yang, Y., E. K. Chung, B. Zhou, K. Lhotta, L. A. Hebert, D. J. Birmingham, B. H. Rovin, and C. Y. Yu. 2004. The intricate role of complement component C4 in human systemic lupus erythematosus. Curr Dir Autoimmun 7:98.

Rovin, B. H., H. Song, L. A. Hebert, T. Nadasdy, G. Nadasdy, D. J. Birmingham, C. Yung Yu, and H. N. Nagaraja. 2005. Plasma, urine, and renal expression of adiponectin in human systemic lupus erythematosus. Kidney Int 68:1825.

Rovin, B. H., Y. Tang, J. Sun, H. N. Nagaraja, K. V. Hackshaw, L. Gray, R. Rice, D. J. Birmingham, C. Y. Yu, D. N. Spetie, A. Aziz, and L. A. Hebert. 2005. Clinical significance of fever in the systemic lupus erythematosus patient receiving steroid therapy. Kidney Int 68:747.

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